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KMID : 0367419790200090021
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Journal of Korean Pediatric Society
1979 Volume.20 No. 9 p.21 ~ p.29
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A Clinical Study on Reye Syndrome
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金秀炯/Kim, Soo hyung
鄭驥燮/高昌俊/陳東植/Chung, Ki Sub/Coe, Chang Jun/Jin, Dong Shick
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Abstract
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This is a clinical study of 33 cases of Reye´s syndrom hospitalized at Yonsei Medical Center from 1971 through Jun 1976.
We observed following results;
1) Among the 33 cases, 6 were diagnosed by liver biopsy, 5 by autosy, and the rest 22 were diagnosed by clinical features and laboratory findings.
2) The sex ratio of male to female was 1.4 : I. The majority of patients were under 2 years -of age. The yearly incidence was increasing year by year and the seasonal prevalence was from late spring through to fall.
3) The common abnormal clinical features were analized;seizure was noticed in all cases and vomitting, tachypnea, hepatomegaly were noticed in two third of patients.
4) The common abnormal laboratory findings were consisted follow blood sugar below 80 mg/dl, SGOT above 40 unit, prolongation of prothrombin time longer than fourteen seconds -was noticed in 90% of patients. And low CSF suger level below 40mg/dl was noticed in 905vo of patients. In pathologic examination, not only the liver but kidney and brain shoved fatty inf iltration.
5) The outcome of these patients according to Huttenlocher´s classification is getting wrose according to the progression of the disease; in stage I two cases were survived without a death, stage I one died in seven, eleven died in fifteen cases of stage IQ and in stage N nine cases .died without survival. Of all motality rate was 63.6%.
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